Gene information
Official symbol HTRA2
Official full name HtrA serine peptidase 2
Gene type protein-coding gene
Chromosome2p13.1
Alias symbolOMI; PARK13
Previous symbolPRSS25
Gene familySerine proteases; PDZ domain containing
Resources
Entrez Gene 27429
HGNC HGNC:14348
Ensembl ENSG00000115317
Vega OTTHUMG00000129957
UCSC uc002smi.2
GO terms: 77 records
GO Description Category LogP Number of genes Detail
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005758 mitochondrial intermembrane space GO Cellular Components -2.32721765 5 More
GO:0006721 terpenoid metabolic process GO Biological Processes -4.89883771 15 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0007005 mitochondrion organization GO Biological Processes -2.05283627 29 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007626 locomotory behavior GO Biological Processes -5.45844211 23 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008344 adult locomotory behavior GO Biological Processes -2.34507176 9 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009408 response to heat GO Biological Processes -9.27499209 13 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0010506 regulation of autophagy GO Biological Processes -5.54010569 34 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010821 regulation of mitochondrion organization GO Biological Processes -7.09757912 23 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0030534 adult behavior GO Biological Processes -6.59104580 21 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0031970 organelle envelope lumen GO Cellular Components -2.85016161 6 More
GO:0032386 regulation of intracellular transport GO Biological Processes -4.43340887 15 More
GO:0034599 cellular response to oxidative stress GO Biological Processes -11.6255265 36 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040014 regulation of multicellular organism growth GO Biological Processes -9.11971182 17 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -11.0338596 16 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071300 cellular response to retinoic acid GO Biological Processes -4.69230219 12 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0097190 apoptotic signaling pathway GO Biological Processes -11.7839485 23 More
GO:0097193 intrinsic apoptotic signaling pathway GO Biological Processes -4.54525889 10 More
GO:1900407 regulation of cellular response to oxidative stress GO Biological Processes -21.4526227 33 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1902882 regulation of response to oxidative stress GO Biological Processes -20.0046302 33 More
GO:1903201 regulation of oxidative stress-induced cell death GO Biological Processes -18.4601079 28 More
GO:1903202 negative regulation of oxidative stress-induced cell death GO Biological Processes -17.0330784 23 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1905286 serine-type peptidase complex GO Cellular Components -11.3739342 10 More
GO:1905370 serine-type endopeptidase complex GO Cellular Components -8.85311859 8 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2001056 positive regulation of cysteine-type endopeptidase activity GO Biological Processes -11.1582582 17 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001235 positive regulation of apoptotic signaling pathway GO Biological Processes -13.4065813 30 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO Biological Processes -7.00132107 13 More
GO:2001242 regulation of intrinsic apoptotic signaling pathway GO Biological Processes -16.0885267 23 More
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO Biological Processes -12.4318822 16 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04210 Apoptosis KEGG Pathway -6.60042966 12 More
hsa04215 Apoptosis - multiple species KEGG Pathway -2.08003997 3 More
hsa05022 Pathways of neurodegeneration - multiple diseases KEGG Pathway -4.18311884 18 More
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
serine protease HTRA2, mitochondrial proteomics acute anterior ST elevation myocardial infarction[diagnosis] acute anterior ST elevation myocardial infarction Hortmann M et al. Eur Heart J Acute Cardiovasc Care. 2017
serine protease HTRA2, mitochondrial proteomics elamipretide[treatment (pharmacotherapy)] acute anterior ST elevation myocardial infarction Hortmann M et al. Eur Heart J Acute Cardiovasc Care. 2017
serine protease HTRA2, mitochondrial proteomics medium predictor ischemia reperfusion injury[prognosis (bad)] acute ST elevation myocardial infarction Hortmann M et al. Int J Cardiol. 2017
All rights reserved: Soochow University Center for Systems Biology